The Mayflower eventually set sail from Plymouth, UK, on 16 September 1620 to start what would prove to be a treacherous transatlantic voyage to America.
On board were more than 100 men, women and children – passengers and crew from different walks of life across England and the Dutch city of Leiden.
Now, 400 years later, a number of special events are planned to mark the anniversary - including an online documentary presented by well-known TV historian Dan Snow which will air on 16 September here on the Mayflower 400 UK website.
The documentary will reflect will reflect the story of the colonists, the impact their arrival had on the Native American people who helped them, and the wider colonial context of this journey.
It will also include a look at some of the cultural projects involved in the commemorative year.
The programme is the first in a series of key events within the Mayflower 400 event and culture programme that culminates with a Four Nations Commemoration Ceremony involving the USA, Netherlands, UK and Wampanoag nations on July 11 next year.
The anniversary programme will importantly involve representatives from the Wampanoag nation who will tell their side of this story in their own words for the first time having been censored or not included in previous anniversaries.
Below you'll find details of news, events, videos and articles relating to the anniversary from across the destinations linked to the Mayflower story.